Mechanical control of cell flow in multicellular spheroids.
نویسندگان
چکیده
Collective cell motion is observed in a wide range of biological processes. In tumors, physiological gradients of nutrients, growth factors, or even oxygen give rise to gradients of proliferation. We show using fluorescently labeled particles that these gradients drive a velocity field resulting in a cellular flow in multicellular spheroids. Under mechanical stress, the cellular flow is drastically reduced. We describe the results with a hydrodynamic model that considers only convection of the particles by the cellular flow.
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ورودعنوان ژورنال:
- Physical review letters
دوره 110 13 شماره
صفحات -
تاریخ انتشار 2013